David Horohov, Ph.D

Professional Profile

Research and/or Professional Experience

August 2003 -  Present; William Robert Mills Chair, Gluck Equine Research Center, Department  of Veterinary Science, University of Kentucky, Lexington, KY

July 1995 - July  2003; Professor of Veterinary Immunology, Department of Pathobiological  Sciences, School of Veterinary Medicine, Louisiana State University, Baton  Rouge, LA

July 1999 -  December 1999; Visiting Scientist, Sabbatical Leave, Animal Health Trust,  Newmarket, UK

December 1997; Visiting  Professor, Department of Animal Sciences, Cook College, Rutgers University, New  Brunswick, NJ.

July 1991 - June  1995;    Associate Professor of Veterinary  Immunology, Department of Veterinary Microbiology and Parasitology, School of  Veterinary Medicine, Louisiana State University, Baton Rouge, LA

September 1990 -  July 2003; Director, School of Veterinary Medicine's Flow Cytometry Facility,  Louisiana State University, Baton Rouge, LA

June 1988 - June  1991; Assistant Professor of Veterinary Immunology, Department of Veterinary  Microbiology, and Parasitology, School of Veterinary Medicine, Louisiana State  University, Baton Rouge, LA

July 1985 - June  1988; Staff Fellow.  Division of Cytokine  Biology, Food and Drug Administration, Bethesda,   MD

Recent Publications

Tompkins D, Hudgens E, Horohov D,  Baldwin CL. 2010. Expressed gene sequences of the equine cytokines  interleukin-17 and interleukin-23. Veterinary Immunology and Immunopathology  133: 309-13

Sturgill TL, Horohov DW. 2010. vaccination  response of young foals to keyhole limpet hemocyanin: Evidence of effective  priming in the presence of maternal antibodies. Journal of Equine Veterinary  Science 30: 359-64

Saulez MN, Godfroid J, Bosman A,  Stiltner JL, Breathnach CC, Horohov DW. 2010. Cytokine mRNA expressions after  racing at a high altitude and at sea level in horses with exercise-induced  pulmonary hemorrhage. American Journal of Veterinary Research 71: 447-53

McDowell KJ, Webb BA, Williams  NM, Donahue JM, Newman KE, Lindemann MD, Horohov DW. 2010. Invited Review: The  role of caterpillars in mare reproductive loss syndrome: A model for  environmental causes of abortion. Journal of Animal Science 88: 1379-87

Horohov DW, Adams AA, Chambers  TM. 2010. Immunosenescence of the equine immune system. Journal of Comparative  Pathology 141: S78-S84

Go YY, Zhang JQ, Timoney PJ, Cook  RF, Horohov DW, Balasuriya UBR. 2010. Complex interactions between the major  and minor envelope proteins of equine arteritis virus determine its tropism for  equine CD3(+) T Lymphocytes and CD14(+) Monocytes. Journal of Virology 84:  4898-911

Dawson TRMY, Horohov DW, Meijer  WG, Muscatello G. 2010. Current understanding of the equine immune response to  Rhodococcus equi. An immunological review of R. equi pneumonia. Veterinary  Immunology and Immunopathology 135: 1-11

Yeargan MR, Lyons ET, Kania SA,  Patton S, Breathnach CC, Horohov DW, Howe DK. 2009. Incidental isolation of  Setaria equina microfilariae in preparations of equine peripheral blood mononuclear  cells. Veterinary Parasitology 161: 142-5

Shakya KP, Miller JE, Horohov DW.  2009. A Th2 type of immune response is associated with increased resistance to  Haemonchus contortus in naturally infected Gulf Coast Native lambs. Veterinary  Parasitology 163: 57-66

Merant C, Breathnach CC, Kohler  K, Rashid C, Van Meter P, Horohov DW. 2009. Young foal and adult horse  monocyte-derived dendritic cells differ by their degree of phenotypic maturity.  Veterinary Immunology and Immunopathology 131: 1-8

Mealey RH, Leib SR, Littke MH,  Wagner B, Horohov DW, McGuire TC. 2009. Viral load and clinical disease  enhancement associated with a lentivirus cytotoxic T lymphocyte vaccine  regimen. Vaccine 27: 2453-68

Lunn DP, Davis-Poynter N,  Flaminio MJBF, Horohov DW, Osterrieder K, Pusterla N, Townsend HGG. 2009.  Equine Herpesvirus-1 Consensus Statement. Journal of Veterinary Internal  Medicine 23: 450-61

Chambers TM, Quinlivan M,  Sturgill T, Cullinane A, Horohov DW, Zamarin D, Arkins S, Garcia-Sastre A,  Palese P. 2009. Influenza A viruses with truncated NS1 as modified live virus  vaccines: Pilot studies of safety and efficacy in horses. Equine Veterinary  Journal 41: 87-92

Adams AA, Katepalli MP, Kohler K,  Reedy SE, Stilz JP, Vick MM, Fitzgerald BP, Lawrence LM, Horohov DW. 2009.  Effect of body condition, body weight and adiposity on inflammatory cytokine  responses in old horses. Veterinary Immunology and Immunopathology 127: 286-94

Wagner B, Hillegas JM, Brinker  DR, Horohov DW, Antczak DF. 2008. Characterization of monoclonal antibodies to  equine interleukin-10 and detection of T regulatory 1 cells in horses.  Veterinary Immunology and Immunopathology 122: 57-64

Vick MM, Murphy BA, Sessions DR,  Reedy SE, Kennedy EL, Horohov DW, Cook RF, Fitzgerald BR. 2008. Effects of  systemic inflammation on insulin sensitivity in horses and inflammatory  cytokine expression in adipose tissue. American Journal of Veterinary Research  69: 130-9

Marti E, Gerber V, Wilson AD,  Lavoie JP, Horohov D, Crameri R, Lunn DP, Antcsak D, Bjornsdottir S,  Bjornsdottir TS, Cunningham F, Derer M, Frey R, Hamza B, Horin P, Hermann M,  Kolm-Stark G, Olafsdottir G, Ramery E, Russell C, Schaffartzik A, Svansson V,  Torsteinsdottir S, Wagner B. 2008. Report of the 3rd Havemeyer workshop on allergic  diseases of the Horse, Holar, Iceland, June 2007. Veterinary Immunology and  Immunopathology 126: 351-61

LeBlanc CJ, Horohov DW, Bauer JE,  Hosgood G, Mauldin GE. 2008. Effects of dietary supplementation with fish oil  on in vivo production of inflammatory mediators in clinically normal dogs.  American Journal of Veterinary Research 69: 486-93

Curriculum Vitae

http://www2.ca.uky.edu/gluck/HorohovDW_CV.asp

Education

Penn State University, University Park, PA; B.S. 1978; Entomology

Purdue University, W. Lafayette, IN; M.S. 1981; Insect Pathology

University of Tennessee, Knoxville, TN; Ph.D. 1985; Immunology

Food and Drug Administration, Bethesda, MD; Post-doc 1988; Cytokine Biology

Areas of Interest