R. Frank Cook, Ph.D

Associate Professor
Research
Teaching

rfcook1@uky.edu
Phone (859) 218-1119
Fax (859) 257-8542

1400 Nicholasville Road
Lexington KY 40546

Professional Profile

Professional Experience

2011 – Present: Research Associate Professor Department of Veterinary Science, Gluck Equine Research Center, University of Kentucky, Lexington, Kentucky.

1998 – Present: Associate Member, Graduate Faculty University of Kentucky.

1998 – 2011: Research Assistant Professor Department of Veterinary Science, Gluck Equine Research Center, University of Kentucky, Lexington, Kentucky.

1991 - 1998: Research Specialist Department of Veterinary Science, Gluck Equine Research Center, University of Kentucky, Lexington, Kentucky.

1989 - 1991: NIH Postdoctoral Researcher Laboratories of Molecular and Development Biology. Ohio Agricultural Research and Development Center. The Ohio State University, Department of Dairy Science 1680, Madison Avenue, Wooster, Ohio 44691.

1983 - 1988: Virologist/Project Leader Equine Virology Unit, Animal Health Trust, Lanwades Park,  Kennett,  Newmarket, Suffolk, Great Britain.

1979 - 1983: Postdoctoral Research Fellow: Tumour Virus Research Group. University of Warwick, Department of Biological Sciences, Coventry, CV4 7AL Great Britain.

Extramural Research Funding

The development of an ISCOM vaccine against EHV-1. Principal Investigator: J .A. Mumford. Co- Principal Investigators: R.  F. Cook and D. Hannant. Agency:  The  Horserace Betting Levy Board. Period:  1985-1988.  Amount:  £190,000

Molecular analysis of antigenic and genetic variation in  equid herpes virus type 1 (subtype 1 and 2) isolates in the United Kingdom. Principal Investigator: R. F. Cook.  Agency:  Equine Virology Research  Foundation. Period:  1986-1988.  Amount:  £60,700

Regulation of EIAV  Replication and Disease. Principal Investigators: R. C. Montelaro, C. J. Issel. Co-Investigator:  R. F. Cook. Agency:  NIH/NIAID Type R01 CA49296. Period:  1996-2001. Amount:  $1,592,313

EIA Vaccine Trial. Principal Investigators: R.  C. Montelaro, C. J. Issel. Co-Investigator:  R. F. Cook. Agency:  Intervet Corp. Period:  2000-2002. Amount:  $316,000

Prospective study of progeny from inapparent carriers of  EIA in a herd of wild Indian horses in Southwest Oklahoma. Principal  Investigator: C. J. Issel. Co-Investigator:  R. F. Cook. Agency:  College of  Veterinary Medicine, Oklahoma State University. Period:  1997-2003. Amount:  $5000 

EIAV Envelope Variation and Vaccine Efficacy. Principal  Investigator: R. C. Montelaro Co-Investigator: R. F. Cook. Agency:  NIH R01 AI25850. Period:  2003 - 2008. Amount:  $1,091,261.

Equine Infectious Anemia Diagnostics. Principal Investigator: C. J.  Issel. Co-Investigator: R. F. Cook. Agency:  Idexx Laboratories. Period:  2006-2011. Amount:  $409,000.

Development of Gene Delivery Approaches to Treat Equine Respiratory  Diseases. Principal Investigator: D. W. Horohov. Co-Principal Investigator: R.  F. Cook. Agency:  Kentucky Science  & Engineering Foundation. Period:   2006. Amount:  $49,573.

EIAV Envelope Variation and Vaccine  Efficacy. Principal Investigator: R. C. Montelaro. Co-Principal Investigator: R. F. Cook. Agency:  NIAID/NIH R01A1025850-21A2. Period:  009-2014. Amount:  UK 5 year budget proposed at $1,737,500.

Molecular characterization of neurovirulent EHV-1 strains.  Principal Investigator: U. B. R. Balasuriya. Co-Principal Investigator: R. F. Cook. Agency:  Grayson-Jockey Club Research Foundation,  Inc. Period:  2010-2012. Amount:  $95,361.

Comparison of in  vitro antiviral activity of herpesvirus DNA polymerase inhibitors against  neuropathogenic and non-neuropathogenic strains of equine herpesvirus-1. Principal  Investigator: U. B. R. Balasuriya. Co-Principal  Investigator: R. F. Cook. Agency:   Kentucky Horse Racing Commission. Period:  2010-2011. Amount:  $40,499.

Testing the  susceptibility of neuropathogenic and non-neuropathogenic equine  herpesviruses-1 strains to antivirals. Principal Investigator: U. B. R.  Balasuriya. Co-Principal Investigator: R.  F. Cook. Agency:  American Quarter  Horse Foundation. Period:  2010-2011.  Amount:  $39,745.

Development of a  genetically defined live attenuated equine herpesvirus-1 vaccine. Principal Investigator: U. B. R. Balasuriya.   Co-Principal  Investigator: R. F. Cook. Agency: Elanco Animal Health.  Period: 2012-2014. Amount: $163,752.

Identification of  genetic factors responsible for establishment of equine arteritis virus carrier  state in stallions. Principal Investigator: U. B. R. Balasuriya.   Co-Principal  Investigator: R. F. Cook.  Agency: USDA-AFRI. Period:   2013–2017.  Amount: $2,925,456.

Development of  Recombinant Vaccines against Porcine Reproductive and Respiratory and Syndrome  (PRRS): Equine Arteritis Virus-Vectored Chimeric Vaccines against PRRS.  Principal Investigator:   U. B. R. Balasuriya.   Co-Principal  Investigator:  R. F. Cook. Agency: Merial. Period: 2013-2015. Amount: $444,571.

Curriculum Vitae

http://www2.ca.uky.edu/gluck/CookRF_CV.asp

Areas of Interest

genetics and genomics, Virology